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 Recommendations for Interventions by the Effective Interventions and Strategies Workgroup

 

Heterosexual - Individual Level Interventions

Heterosexual - Prevention Case Management

Heterosexual - Group Level Interventions

Heterosexual - Community Level Interventions

Heterosexual - Counseling and Testing

Heterosexual - Partner Notification

Heterosexual - Drug Treatment

Heterosexual - Other

Heterosexual Interventions Summary (includes 2007 updates) (PDF 212kb)

2007 Heterosexual Interventions (new only) (PDF 60kb)

Heterosexual

Literature Summary

Individual-Level - Heterosexual
El-Bassel, N., Witte, S.S., Gilbert, L., Wu, E., Chang, M., Hill, J., and Steinglass, P. (2005) Long-Term Effects of an HIV/STI Sexual Risk Reduction Intervention for Heterosexual Couples.  AIDS and Behavior, Vol. 9, No. 1, 1 - 13
Subpopulation Researched Intervention Design Evaluated Outcome
Heterosexual Couples

This randomized trial wanted to examine the efficacy of a relationship based HIV/STI prevention intervention.  A total of 217 heterosexual couples were randomly assigned to one of three intervention conditions.  1) Six sessions to both partners, 2) the same intervention to the woman alone, or 3) a one session health education (control) provided to the female participant only.  Each intervention incorporated concepts from the ARRM, ecological perspective, information from the development phase, and an NIMH HIV/STI prevention with couples trial from 1998.

During the 12 month follow-up post intervention interview, results showed that the intervention was effective in reducing unprotected sex for those who participated in the intervention conditions 1 and 2 compared to those who participated in the health education intervention.  However, there was not a significant difference when comparing whether couples attended together or the woman received the intervention alone.

Prevention Case Management - Heterosexual                       Back to Top

The CDC has endorsed Prevention Case Management (PCM) as an effective intervention to reach HIV positive and/or very high-risk HIV negative persons.  PCM is a client-centered HIV prevention activity with the fundamental goal of promoting the adoption and maintenance of HIV risk reduction behaviors by clients with multiple, complex problems and risk reduction needs.  PCM provides client-centered, multiple-session HIV risk reduction counseling while using the service brokerage of traditional case management to address competing needs that may make HIV prevention a lower priority.  This HIV prevention activity addresses the relationship between HIV risk and other issues such as substance use, mental health, adherence issues, social and cultural factors, and physical health problems.  While PCM has yet to be rigorously evaluated, intensive case management interventions for clients with multiple, complex problems have been shown to be effective in other health fields.

CDC HIV Prevention Case Management – Guidance   September 1997

CDC HIV Prevention Case Management – Literature Review and Current Practice   September 1997

CDC Abbreviations and Acronyms

Group-Level - Heterosexual                                                    Back to Top
Kalichman, S.C., Sikkema, J., Kelly, J.A., Bulto, M., (1995) Use of a brief behavioral Skills Intervention to Prevent HIV Infection Among Chronic Mentally Ill Adults. Psychiatric Services 46(3), 275-280
Subpopulation Researched Intervention Design Evaluated Outcome
Heterosexual

This is a brief behavioral skills intervention conducted in small groups during four 90 minute sessions.  Sessions were: 1) AIDS risk reduction education; 2) behavioral skills to reduce AIDS risk; 3) communication and negotiation skills; and 4) review & reinforcement.   The goal of the intervention was to inform adults about HIV/AIDS and ways they can protect themselves and others from contracting HIV.  The intervention is based on theory of reasoned action, social cognitive theory, and information-motivation-behavior skills (IMB) model.  The intervention was originally conducted in two psychiatric clinics in Milwaukee, Wisconsin.  The participants (27 men and 25 women) were recruited and randomly assigned to either the immediate intervention, or the four-week waiting list control group. 

An intervention package, Let’s Chat, is available from Sociometrics (www.socio.com).  Check web site for the package price.

Overall, the researchers concluded the intervention had a positive, short-term effect on sexual risk behaviors.  Of the 52 participants who completed the baseline assessment, 44 (85%) completed the intervention.  Completion was defined as having attended a minimum of two of the four sessions.  When compared with the waiting list control group, the immediate intervention group reported changes in condom-use and AIDS risk knowledge, and intentions to change their risk behavior.  The immediate group also reported a substantial reduction in rates of unprotected sexual intercourse and an increase in condom use.

Baker S et al. (1999) Personal communication
Subpopulation Researched Intervention Design Evaluated Outcome
Women Choices Project. Women randomly assigned to Relapse Prevention intervention (experiment) or health education and social support intervention (control). Both interventions 16-session, 2-hour weekly groups. Both groups reduced number of risky sexual acts at 4 months and change is sustained at 12 months. No difference between groups. Both groups also increased and maintained safer sex negotiation skills.
Basen-Engquist K, Coyle K, et al. (2001) Schoolwide Effects of a Multicomponent HIV, STD, and Pregnancy Prevention Program for High School Students. Health Education & Behavior 28 (2): 166-185.
Subpopulation Researched Intervention Design Evaluated Outcome
Youth School-based Safer Choices program, a multicomponent, behavioral-theory-based HIV, STD, and pregnancy prevention program. 20 urban high schools randomized into intervention and control. At 19 months, decreased frequency of sex without a condom. At 31 months, less sexual intercourse without a condom with fewer partners. Program did not influence prevalence of recent sexual intercourse. Cost-effectiveness study showed that Safer Choices is a cost saving program under a wide range of estimates (Wang LY et al.).
Concern: Setting specific?
Cohen D, Dent C, et al. (1991) Condom Skills Education and Sexually Transmitted Disease Reinfection. Journal of Sex Research
28(1): 139-144.
Subpopulation Researched Intervention Design Evaluated Outcome
POC (mostly African-Am) Los Angeles, California. 192 STD clinic patients most of who were African-Am. Increase familiarity and skill with condoms was a single group session (30 mins) for men and women registered at the STD clinic. The brief condom skills education session was led by a female health educator during regular clinic hours at the STD clinic. Compared with controls, men and women exposed to the group intervention in the STD clinic waiting room were approximately half as likely to return to the clinic within the next 12 months with a new STD. This was a significant decrease in return rates.
Concern: Setting specific?
Cohen D, MacKinnon DP, et al. (1992) Group Counseling at STD Clinics to Promote Use of Condoms. Public Health Reports 107(6): 727-730.
Subpopulation Researched Intervention Design Evaluated Outcome
POC (mostly African-Am) Los Angeles, California. 426 STD clinic patients most of who were African-Am. Small group format while patients were waiting for their STD clinic appointments. Groups were 10 to 25 people per session. Led by African American female health educator – soap opera-formatted video showing condom use as socially acceptable, a facilitated group discussion on methods of preventing STDs and promoting condom use and role playing, skill-building exercises to enhance condom negotiation with sex partner. The rate of STD reinfection was significantly lower for men who participated in the intervention than for men who did not participate in the intervention.
Concerns: No effect for women. Setting specific?
DiClemente RJ, Wingood GM (1995) A Randomized controlled trial of an HIV sexual risk-reduction intervention for young African-American Women. Journal of American Medical Association October 25; 274(16): 1271-1276.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/
young women

"SISTA Project"

Peer mediated 128 sexually active women aged 18-29. Five 2-hour weekly group sessions. Session focused on gender, ethnic prided, knowledge of HIV risk behaviors, prevention strategies, sexual assertiveness, modeling and role playing; correct condom use; norm setting exercises and coping skills, sexual self-control, communication skills, and practicum’s.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

At 3-month follow-up. The social skills intervention was effective in increasing consistent condom use.
El-Bassel N, Schilling RF (1992) 15- Month Follow-up of Women Methadone Patients Taught Skills to reduce Heterosexual HIV Transmission. Public Health Reports 107(5): 500-4
Subpopulation Researched Intervention Design Evaluated Outcome
IDU/ POC (African-Am/ Hispanic) 15-month follow-up of study summarized above (Schilling RF, EL-Bassel et al. (1991) Building Skills of Recovering Women Drug Users to Reduce Heterosexual AIDS Transmission. Public Health Reports 106(3): 297-304). Compared to the information-only group, women in the skills-building group showed an increase in frequency of condom use at 15-month follow-up. The groups did not differ significantly in number of sex partners.
Eldridge, GD, St. Lawrence JS, Little CE et al. (1997) Evaluation of an HIV risk reduction intervention for women entering inpatient substance abuse treatment. AIDS 9: 62-77.
Subpopulation Researched Intervention Design Evaluated Outcome
Women/Drug Use 117 drug-using women court-ordered into inpatient drug tx. Compared effectiveness of an educational intervention and a behavioral skills training intervention at reducing sexual risk. Both groups reported high rates of sexual risk prior to intervention. At 2-month follow-up, women in skills training groups showed improvement in communication skills, condom application skill, and condom use. Both groups showed decreased drug use and drug-related high-risk sex activity.
Concern: short follow-up
Hobfoll SE, Jackson AP (1994) Reducing Inner-City Women’s AIDS Risk Activities: A Study of Single, Pregnant Women. Health Psychology 13(5): 397-403.
Subpopulation Researched Intervention Design Evaluated Outcome
Pregnant Women 206 participants, who were single pregnant women, attended four 90-120 min. group sessions of 2-8 women, taped segments of assertiveness, negotiation, planning, and AIDS prevention skills including role plays, cognitive rehearsal, formulate health action plan. 6 mo. Follow-up improvement in condom use for vaginal sex, condom and spermicide acquisitions for intervention and not for control.
Concern: Applicability to non-pregnant persons.
Howard M, McCabe J (1990) Helping teenagers postpone sexual involvement. Family Planning Perspectives 22:21-6.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Youth Henry W. Grady Memorial hospital, recruited 536 students from their low-income population.  Those recruited were less than 16 years old, part of the hospital’s family planning program, and were recruited through medical records.  Intervention was peer-led 5 sessions, emphasis on postponing sexual involvement, discussing peer pressures, skill practice to resist pressure.

18 month follow-up fewer students initiated sex in intervention group.
Concern: Emphasis on postponing sex.

Jemmott JB, Jemmott LS et al. (1992) Reductions in HIV risk-associated sexual behaviors among black male adolescents: Effects of an AIDS Prevention Intervention. American Journal of Public Health 82(3): 372-377
Subpopulation Researched Intervention Design Evaluated Outcome
POC/Youth (African Am) 157 participated in 5-hour intervention based on theory of reasoned actions.  Intervention provided information, video, games, exercises, and skills building. The control group received an intervention on career opportunities. 3 mo. follow-up, fewer sexual partners in intervention group, more condom use and less anal intercourse.  Cost-effectiveness data: Pinkerton SD, Holtgrave DR, and Jemmott JB (2000).  Economic Evaluation of HIV Risk Reduction Intervention in African-American Male Adolescents.  JAIDS 25(2): 164-72.
Jemmott JB, Jemmott LS, Fong GT (1998) Abstinence and safer sex HIV risk reduction interventions for African-American Adolescents: A randomized controlled trial. Journal of the American Medical Association 279: 1529-36.
Subpopulation Researched Intervention Design Evaluated Outcome
African-Am Youth Randomized controlled trial with 3, 6, and 12 month follow-up.  659 male and female African-American 6th and 7th graders.  Eight 1 hour modules, adult facilitators or peer co-facilitators.  Abstinence intervention stressed delaying intercourse or reducing frequency; safer sex intervention stressed condom use; control intervention concerned health issues unrelated to sexual behavior. Abstinence:  less likely to report sex at 3 months, but not at 6 or 12 months.  Safer-sex:  more consistent condom use than control at 3 months and higher frequency of condom use at all follow-ups.  Among youth sexually experienced at baseline, safer-sex intervention participants reported less sex at 3 months than the control intervention participants.  Additionally, those attending the safer sex intervention reported less sex at 6 months and 12 months than the abstinence and control interventions.  No differences in intervention effects with adult facilitators compared with peer co-facilitators.
Kalichman SC, Cherry C and Browne-Sperling F (1999) Effectiveness of a Video-Based Motivational Skills-Building HIV Risk-Reduction Intervention for Inner-City African American Men. Journal of Consulting and Clinical Psychology 67:959-966.
Subpopulation Researched Intervention Design Evaluated Outcome
African-Am men 117 heterosexually active African-American men recruited from public clinic. Randomly assigned to either a 6-hr video-based small group motivational-skills intervention or a 6-hr video-based HIV education comparison group. Men in motivational-skills group decreased rate of unprotected vaginal intercourse and used more condoms at 3 months. Both groups showed increased condom use at 6-month follow-up.
Kelly JA, Murphy DA et al. (1994) The effects of HIV/AIDS Intervention Groups for High-risk Women in Urban Clinics. American Journal of Public Health 84(12): 1918-1922
Subpopulation Researched Intervention Design Evaluated Outcome
Women (African-Am) 197 women at urban primary care clinic randomly assigned to intervention or control. Intervention included four 90 min group sessions and 1-month group follow-up with 8-10 women in-group with two leaders. Provided information, role-plays, managing ‘triggers’, group problem solving and active support. Comparison group attended sessions on health topics unrelated to AIDS. At 3-month follow-up, intervention group had increased communication and negotiation skills, decreased UVI, and increased condom use. Control group showed no change.
Concern: short follow-up
Kirby D, Barth RP et al. (1991) Reducing the risk: Impact of a new curriculum on sexual risk taking. Family Planning Perspectives 23(6): 253-263.
Subpopulation Researched Intervention Design Evaluated Outcome
Youth A school-based program conducted over 15 classroom periods. 758 students were assigned to a treatment or control group.   The treatment group received the Reducing the Risk curriculum that was based on several somewhat interrelated theoretical approaches.  Those assigned to the comparison group received a mandatory health education class. Intervention group had prolonged first onset of intercourse than control group. After 18 months, 29% of the intervention group had initiated intercourse compared with 38% of the control group. Outcomes regarding unprotected sex refer generally to birth control, not specifically to condoms.
Concerns: Small effect, if any, for high-risk sexually active youths. Setting specific?
Levy JA, Fox SE (1998) The Outreach-assisted Model of Partner Notification with IDUs. Public Health Report 113(S-1): 160-9.
Subpopulation Researched Intervention Design Evaluated Outcome
Youth School-based program with 15 school districts randomly assigned to 3 conditions a) parent interactive; b) parent non-interactive and c) wait list. Intervention was lecture, small group discussion, and skills building to: resist social pressures; obtain preventive practices, role-play, practice, and homework. 10 session provided to 7th graders and 5 sessions provided to the 8th graders. Intervention groups use of condoms and foam from 14% to 24%. Had sex less often. No difference in use of condoms alone.
Concern: Setting specific?
Magura S, Kang S. et al. (1994) Outcomes of Intensive AIDS Education for Male Adolescent Drug Users in Jail. Journal of Adolescent Health 15(6): 457-463.
Subpopulation Researched Intervention Design Evaluated Outcome
Young POC/ drug users NYC DOC Adolescent Reception and Detention Center. 157 youths aged 16-19, most were African-American or Hispanic. 4 1-hour small-group sessions of eight led by male counselor. Sessions focused on health education issues relevant to male adolescent drug users, with an emphasis on HIV/AIDS. Group activities included role-play and rehearsal techniques. Youth in the intervention were more likely to use condoms during vaginal, oral or anal sex, had fewer high-risk sex partners, and had more favorable attitudes toward condoms than youth not in the intervention.
Comment: None of youth admitted to using injection drugs; however, there was a high incidence of crack and intranasal cocaine use. Curriculum focused on sexual risk reduction.
Main DS, Iverson DC et al. (1994) Preventing HIV Infection Among Adolescents: Evaluation of School-Based Education Programs. Preventive Medicine 23(4):409-417.
Subpopulation Researched Intervention Design Evaluated Outcome
Youth School-based program conducted over 15 sessions (40 hours). Program consist of 3 HIV knowledge sessions, 2 normative determinates of risky behavior, one on teen vulnerability and eight on development skills to identify and manage risking situations. At 6-month follow-up, sexually active students reported significantly fewer partners and greater frequency of condom use.
Concern: Setting specific?
Malow RE, West JA et al. (1994) Outcome of Psychoeducation of HIV risk reduction. AIDS Education and Prevention 6(2): 113-125.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Drug use (African American cocaine users) 152 African American males at in-patient tx program participated in group-level sessions. Non-peer led, held for 2 hours over 3 consecutive days, 6-8 people. Sessions included HIV knowledge/risk; demonstrated cleaning works, condom use, condom negotiating, and skills-building exercises; and review and discussion of HIV testing procedures. 47.5% of intervention group participants reported having more than one partner at three-month follow-up compared to 76% at the baseline in the comparison group.  The change from 76% at baseline to 59% at the follow-up was considered to be not statistically significant.  Sexual risk taking in those receiving the intervention decreased from 75% (pre intervention) to 32% (follow-up).
The National Institute of Mental Health (NIMH) Multisite HIV Prevention Trial Group (1998). The NIMH Multisite HIV Prevention Trial: Reducing HIV sexual risk behavior. Science 280: 1889-94.
Subpopulation Researched Intervention Design Evaluated Outcome
POC Project Light. Randomized, controlled trial with 3 high-risk populations at 37 inner city, community-based clinics at 7 US sites. 1855 control and 1851 intervention participants, mostly African-American or Hispanic. Experimental condition: Small-group (5-15), twice weekly 7 session program, 90-120 minutes per session. Separate male and female groups. Co-led by a male and a female facilitator. Control condition: 1-hour AIDS education session that included videotape and Q&A period. Both groups decreased frequency of unprotected sex at follow-up. Compared to controls, intervention group reported fewer unprotected sexual acts, had higher levels of condom use, and were more likely to use condoms consistently over a 12-month follow-up period. In intervention group, more sessions attended associated with greater behavior change. No difference in overall STD reinfection rate. Among men recruited from STD clinics, lower gonorrhea incidence at follow-up.
Nyamathi AM, Flaskenis J et al. (1994) Evaluation of Two AIDS Education Programs for Impoverished Latina Women. AIDS Education and Prevention 6(4): 296-309.
Subpopulation Researched Intervention Design Evaluated Outcome
POC Women
drug using/homeless
The purpose was to evaluate and contrast the effectiveness of two culturally sensitive AIDS education programs.  131 women participated in the traditional program where they received one hour of AIDS education and community resource information.  82 women participated in a specialized program where the information was extended to include reinforcement of risk skills and enhancement of self-esteem and control.

Over the two-week interval, significant improvements were found in both groups for all cognitive and psychological variables, except problem-focused coping.  High-risk IV drug use (in those who reported this behavior during the pre test) decreased from 18 to 7 in the traditional group and from 14 to 0 in the specialized group.  Likewise, reports of non-IV drug use and sexual activity with multiple partners decreased in both groups.
Concern: Very short follow-up.

O’Donnell CR, O’Donnell L et al. (1998) Reductions in STD infections subsequent to an STD clinic visit: Using video-based patient education to supplement provider interactions. Sexually Transmitted Diseases 25(3): 161-168.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/African Am and Hispanic males

"VOICES/VOCES"

2,004 adult males in South Bronx, New York. Tested video-based STD prevention. Random assignment to three groups: video plus discussion, video only, usual clinic services (control). Interactive session was small group format (three to eight patients) at the clinic and facilitated by an STD counselor. Two culturally sensitive videos (Let’s Do Something Different for African Americans and Porque Si for Hispanics).

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

Men who participated in experimental groups had significantly lower rates of new STD infection than those in comparison group. No difference between video only group and video plus discussion group. Clients with multiple sex partners experienced greatest effect.
Raj A, Amaro H, Cranston K, et al. (2001). Is a General Women’s Health Promotion Program as Effective as an HIV-Intensive Prevention Program in Reducing HIV Risk Among Hispanic Women? Public Health Reports 116: 599-607.
Subpopulation Researched Intervention Design Evaluated Outcome
Latina Study included 162 Hispanic women ages 18 to 35, most of them low-income immigrants, in Boston area. Assessed whether participation in an HIV intensive prevention program or in a general women’s health promotion program led to greater risk reduction than being in the wait-list control group. Both interventions lasted 12 weeks (12 sessions of 90-120 minutes each) and were group-level interventions. Measurements at baseline, intervention completion, and 3 months. Both interventions showed increased condom use at post-test and follow-up. HIV intensive program participants also reported increased safer sex negotiation. Health promotion program participants reported increased HIV testing.
Rhodes R, Wolitski RJ et al. (1992) An experiential program to reduce AIDS risk among female sex partners of injection drug users. Health and Social Work 17:261-272.
Subpopulation Researched Intervention Design Evaluated Outcome
Women (Sex partners of IDUs) 69 women recruited though street outreach participated in 3 90-min group sessions held on consecutive days then a fourth session one week later and underwent HIV C/T. Sessions focused on AIDS education, condom use, needle cleaning, negotiation, problem-solving skills building, referrals, and post-intervention weekly support groups. At immediate post-intervention, 91% reported having made positive changes to reduce AIDS risk and 68% of women who did not use condoms before intervention reported they had since entering intervention (no control).
Rotheram-Borus MJ, Koopman C et al. (1991) Reducing HIV sexual risk behaviors among runaway adolescents. Journal of American Medical Association 266(9): 1237-1241.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Youth

"Street Smart"

Non-random control 197 runaways. Small group sessions 90-120 min., 4 days/week. Each up to 30 sessions at least 3 private session, develop soap opera dramas, review videos, and skills coping.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

3 and 6-month follow-up. Increased number of sessions associated with increased condom use and decreased risk behaviors. An update of the intervention in 1997 CDC compendium shows similar results.
Schilling RF, EL-Bassel et al. (1991) Building Skills of Recovering Women Drug Users to Reduce Heterosexual AIDS Transmission. Public Health Reports 106(3): 297-304.
Subpopulation Researched Intervention Design Evaluated Outcome
Women/ POC 91 African-American and Hispanic women enrolled for at least 3 months in five clinics in large methadone maintenance program in NYC. Non-peer led skills-building groups held five 2-hour sessions offered to groups of 9-10. Topics included: HIV 101; identification of high-risk sexual practices; discussion of barriers to adopting safer sex practices; discussion of negative associations with condoms; condom use skills; role-played negotiation of condom use; assertiveness; problem solving; and communication skills involving safer sex scenarios. Comparison group received one session of AIDS information routinely provided by the clinic. The skill-building intervention group showed statistically significant higher use of condoms than those in the control group at follow-up. Participants also more comfortable taking and carrying condoms, talking about safer sex with partners, had more favorable attitudes toward condoms. No drug use differences between groups.
Comment: Initial follow-up was 2-week post.
Schilling RF, Ivanoff A et al. (1994) HIV-related risk reduction among women offenders in jail and in the community.    X International Conference on AIDS. 10,43
Subpopulation Researched Intervention Design Evaluated Outcome
Women/Drug Use 159 Drug-abusing female offenders, approaching release from a 3-12 month sentence, were recruited from Rikers Island. Women were randomly assigned to (1) 8 group session conducted in prison and 8 individual session in the community post-release, focussing on AIDS information; condom use; needle-cleaning; and negotiation skills building and social support; or (2) an information-only. At follow-up, there was a trend for intervention participants to report greater condom use improvements.
Sikkema KJ, Winett RA et al. (1995) Development and Evaluation of an HIV-Risk Reduction Program for Female College Students. AIDS Education and Prevention 7(2): 145-159.
Subpopulation Researched Intervention Design Evaluated Outcome
College women 43 heterosexual college women participated in four 75 to 90-min. sessions held over a one-month period with groups of seven to 10 participants. Female doctoral students served as group mediators. The intervention covered topics such as risk behavior education, behavioral self-management, assertiveness training, decision-making, safer sex negotiation, condom use and maintenance of risk-reduction behavior. The control group received one 90-min. session covering the same topics but using a didactic education approach. The intervention was effective at improving one key determinant of sexual risk behavior: sexual assertiveness and communication skills. The skill-building participants showed greater improvement from baseline to the immediate follow up in overall assertiveness skill, in the sum of four components of skill and in two of the four components: acknowledgment of partners’ request for sex and suggestion of alternative lower-risk behavior.
Concern: Applicability of results to other (non-college, high-risk) populations.
Shain RN, Piper JM, Newton ER, et al. (1999) A randomized, controlled trial of a behavioral intervention to prevent sexually transmitted disease among minority women. New England Journal of Medicine 340: 93-100.
Subpopulation Researched Intervention Design Evaluated Outcome
Women of Color 424 Mexican-American and 193 African-American women with nonviral STDs.  Randomized trial.  Intervention 3 weekly small-group sessions, 3-4 hours each.  5-6 women per group and female facilitator, all of same race/ethnicity.  Sessions designed to help recognize personal susceptibility, commit to changing behavior, and acquire skills.  Based on AIDS Risk Reduction Model.  6 and 12 mo follow-up High rates of session attendance and retention in study.  This intervention decreased the rates of Chlamydia and gonorrheal infection among Mexican-American and African American women at high risk for sexually transmitted disease; rates of subsequent infection was significantly lower in intervention group at both follow-ups.
Comment: Very strong study design.
Stanton BF, Li X et al. (1996) A Randomized, Controlled Effectiveness Trial of an AIDS Prevention Program for Low-Income African-American Youth. Archives of Pediatrics and Adolescent Medicine. 150(4): 363-372.
Subpopulation Researched Intervention Design Evaluated Outcome
African-Am youth Public Housing developments/rural campsites. 383 African-American youth, 9 to 15 years of age, in peer groups. 7 weekly sessions (1½ hour each) and one day-long session. Each session led by a pair of interventionists, recruited from the community, most of whom were African-American. Group sessions included communication and negotiating skills, value clarification, goal setting and peer norms. Small-group discussions, lectures, videos etc. In session 7 the group developed community projects with intervention messages. Condom use in the short term (6 month after intervention) showed significant improvement for intervention youth compared with control youth. Long-term follow-up (2 years) showed that intervention youth were less likely than control youth to adopt a risk behavior, though they were not less likely to experiment with a risk behavior.
Concern: Condom use difference disappeared at 12-month follow-up.
St. Lawrence JS, Brasfield TL et al. (1995) Cognitive-behavioral Intervention to Reduce African-American Adolescents’ Risk for HIV Infection. Journal of Consulting and Clinical Psychology 63(2): 221-237.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Youth (African- Am) Public health clinic serving low-income families in a mid-size southern US city. 246 inner-city youth ages 14-18. Intervention was 8 group sessions (1½ to 2 hours each) of 5 to 15 participants. Group sessions were co-led by trained facilitators. The group members used role-playing techniques and practiced skills-building activities in smaller groups of two to three persons. Sessions included HIV/AIDS education; peer pressure and sexual decision making; communication and assertiveness skills-building activities; meeting an HIV positive youth; discussion on the most beneficial components of the intervention and how they increased self-efficacy. Control group received 2 hours of education. Male and female adolescents who received the intervention increased condom use significantly. The males in the group also lowered their rates of unprotected intercourse to a greater extent than did males in the information-only intervention. The females, who received skills training, compared with those who received information only, decreased the frequency of unprotected intercourse. Thus, the skills training intervention was more successful both in lowering risky behaviors and in sustaining safe alternatives such as condom use among youth who remained sexually active.
St. Lawrence JS, Brasfield TL, and O’Bannon RE (2002). Reducing STD and HIV Risk Behavior of Substance-Dependent Adolescents: A Randomized Controlled Trial. Journal of Consulting and Clinical Psychology 70(4): 1010-1021.
Subpopulation Researched Intervention Design Evaluated Outcome
Youth Conducted in Mississippi with high-risk adolescents in two residential drug treatment programs. Assessed 3 interventions designed to increase safer sex behaviors of substance-dependent adolescents. Mixed gender cohorts of 6 to 10 adolescents met three times each week over a 4-week period for a total of twelve 90-minute sessions. Total N=161 participants (68% male, 75% white, 22% African American). Randomly assigned to either a health information intervention (I only); information plus behavioral skills safer sex training (i.e., correct condom use, partner negotiation, refusal of unwanted sexual invitations, and peer information provision) (I+B); or the same experimental condition plus a motivation component that confronted adolescents’ illusion of invulnerability and then emphasized their ability to prevent the negative outcome (I+M+B). The intervention conditions were in addition to the existing drug treatment programs. Assessments at baseline, 6 months, and 12 months. The I+B and I+M+B conditions, as compared with the I only condition: (a) produced more favorable attitudes toward condoms; (b) reduced the frequency of unprotected vaginal sex; and (c) increased behavioral skill performance, frequency of condom-protected sex, percentage of intercourse occasions that were condom protected, and number of adolescents who abstained from sex. The I+M+B intervention was more resistant to decay.
Walters HJ, Vaughn RD (1993) AIDS risk reduction among a multi-ethnic sample of urban high school students. Journal of American Medical Association 270(6): 725-730.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Youth School-based program with two intervention schools and two comparison schools, 1316 students. Six 1-hour lessons on AIDS facts, risk appraisal, personal values, norm change, role-play, negotiating skills, and how to use condoms. At the three-month follow-up, significant efforts in five of the eight variables (knowledge, benefits, norms, self-efficacy and behaviors) favored those students who participated in the intervention.  The intervention appeared to have the greatest effect on involvement in sexually intercourse, was associated with favorable tends in STD rates, but did not effect sexual abstinence.
Concern: Setting specific?
Wenger NS, Greenberg JM et al. (1992) Effect of HIV Antibody Testing and AIDS Education on Communication About HIV Risk and Sexual Behavior. Annals of Internal Medicine 117(11): 905-911.
Subpopulation Researched Intervention Design Evaluated Outcome
College students 435 university students at outpatient student health clinic. Consisted of a multimedia presentation in a single 1-hour small-group session. Led by physicians familiar with HIV counseling. The session began with an 11 min video, 15 min scripted lecture (AIDS 101, routes of transmission, and safer sex behaviors, obstacles to using condoms, communication with sex partners, and the role of drugs and alcohol in promoting unsafe sex behaviors). Following the lecture, participants engaged in 15 minutes of role-play and 15 minutes group discussion. Students randomly assigned to get HIV testing. After 6 months, heterosexual university student who received education about HIV infection plus HIV testing were more likely compared with students in the control group to increase communication with their sexual partners about the risk of HIV infection. No difference in condom use or number of sexual partners.
Concern: Applicability of results to other (non-college, high-risk) populations.
Community-Level - Heterosexual                                          Back to Top
The CDC AIDS Community Demonstration Projects Research Group (1999) Community-level HIV intervention in 5 Cities: Final outcome data from the CDC AIDS Community Demonstration Projects. American Journal of Public Health 89: 336-45.
Subpopulation Researched Intervention Design Evaluated Outcome
Multiple sub-pops Role model stories distributed with condoms and bleach by community members who encouraged behavior change. Quasi-experimental design. Over 3 years, 15,205 interviews conducted with 10 intervention and comparison community pairs. Outcomes measured on stage-of-change scale.
Sub-populations: IDUs, their female sex partners, sex workers, NGI MSM, high-risk youth, residents of areas with high STD rates.
By end of intervention, 54% of persons interviewed in intervention communities had been exposed to materials in past 3 months. Consistent condom use with main and non-main partners, esp. for VI, and increased condom carrying, greater in intervention communities. At individual level, respondents recently exposed to intervention more likely to carry condoms and to have higher stage-of-change scores for condom and bleach use.
Lauby JL, Smith PJ, Stark M et al. (2000) A community-level HIV prevention intervention for inner-city women: Results of the Women and Infants Demonstration Projects. American Journal of Public Health 90 (2): 216-222.
Subpopulation Researched Intervention Design Evaluated Outcome
Women (mostly African-American)

"Real AIDS Prevention Project (RAPP)"

Low-income, primarily AA women in 4 urban communities. Pre-post surveys in matched intervention and comparison communities. Targeted sexually active. Activities: development and distribution of prevention materials, mobilization of peer network of community volunteers, delivery of prevention messages by trained outreach specialists through individual contacts and small-group activities. Role model stories. A total of 225-240 women interviewed in each intervention and comparison community in each wave of survey.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

After 2 years, significant increase (11%) in rates of talking with main partner about condoms, also significant increase (13%) in proportion who had tried to get main partners to use condoms. Almost significant (p=054) decrease (9%) in never using condoms. Effects stronger for women who reported exposure to intervention. No intervention effects for condom use during most recent sex or for consistent condom use, but both groups increased over time. Trends for condom use for other partners similar but not significant.
Sellers D, McGraw S et al. (1994) Does the promotion and distribution of condoms increase teen sexual activity? Evidence form an HIV prevention program from Latino youth. American Journal of Public Health 84(12): 1952-1959.
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Youth (Latinos) The purpose of the study was to see if condom distribution increases sexual activity.   Boston was the intervention city and Hartford was the comparison city.  The intervention included condom distribution, workshop in schools, group discussion, large community events, presentations, and door-to-door street outreach. Males, in the intervention city wee less likely to initiate first sexual activity.  Females were less likely to have multiple sex partners.  Conclusion:  HIV prevention programs that include condom distribution did not increase sexual activity.
Concern: Applicability.
Sikkema KJ, Kelly JA, Winett RA et al. (2000) Outcomes of a randomized community-level HIV prevention intervention for women living in 18 low-income housing developments. American Journal of Public Health 90: 57-63.
Subpopulation Researched Intervention Design Evaluated Outcome
Low-income women 690 low-income women living in 18 housing developments. Community-level intervention in 5 US cities. HIV risk reduction workshops and community prevention events implemented by women who were popular opinion leaders. At 12-month follow-up, proportion of women who had any UI decreased and percentage of protected sex acts increased in intervention group. Little behavior change in control group.
Tross S, Abdul-Quader AS, Simons PS, Sanchez M, Silvert HM (1993). Evaluation of a peer outreach HIV prevention program for female partners of injecting drug users (IDUs) in New York City. IX International Conference on AIDS. Berlin, June 1993 [abstract PO-D13-3737].
Subpopulation Researched Intervention Design Evaluated Outcome
Female sex partners (FSPs) of IDU 658 FSPs in high drug-use housing project in NYC randomly assigned to intervention or control. Intervention was peer outreach and media distribution program. Significant increase in percentage of intervention group always using condoms and decrease in percentage never using condoms. No change in control group.
Comment: Information from abstract only so few details available.
Vincent L, Clearie A et al (1987) Reducing adolescent Pregnancy through school and community-based education. Journal of American Medical Association 254(4): 3382-3386
Subpopulation Researched Intervention Design Evaluated Outcome
POC/ Youth Intervention to reduce adolescent pregnancies. Three-hour courses for teachers. Sex education in all grades. Training for clergy, church leaders and parents. Mass media speakers. 2-year follow-up. Pregnancy rates decreased by half in target county only.
Concern: Applicability.
HIV Antibody Counseling & Testing - Heterosexual                Back to Top
Bevier P, Ewing W et al. Effects of counseling on HIV risk behaviors in patient at a New York City sexually transmitted disease clinic. VII International Conference on AIDS 7, 458.
Subpopulation Researched Intervention Design Evaluated Outcome
Women (STD clients) 1016 total STD clinic patients received one-session of HIV risk behavior counseling. Total percentage of women unknown. At 6-month follow-up, women significantly reduced their total number of partners from 5.9 to 4.3 in a 6-month period. Condom use ‘increased slightly’, but sex partners of IDs reported condom use only 10% of the time.
Corby N, Barchi P et al. (1990) Effects of condom skills training and HIV testing on AIDS prevention behaviors among sex workers. VI International Conference on AIDS. 6, 267.
Subpopulation Researched Intervention Design Evaluated Outcome
Sex workers 64 sex workers were randomly selected into four groups. Group 1: HIV counseling/testing. Group 2: 15-min. AIDS prevention program with rehearsal of condom use. Group 3: both 1 & 2. Group 4: No intervention At 1-month follow-up, women in group 3 showed increase in condom use during vaginal intercourse with customers. Women in group 1 reported a decrease in proportion of condom us during oral sex with customers.
Higgins DL, C Galavotti et al. (1991) Evidence for the Effects of HIV Antibody Counseling and Testing on Risk Behaviors. Journal of American Medical Association 266(17): 2419-2429.
Subpopulation Researched Intervention Design Evaluated Outcome
General A review of 10 studies on the effects of C/T on behavior change (condom use, reduction of sexual partners) of heterosexuals (actual study reviews several populations). Of the studies: 80% showed increase in condom use; 30% showed increase in safer sex (undefined) and 1% showed decrease in sexual partners (Note: most were measuring for condom usage – 1% may not be reflective of real change).
Kamb ML, Fishbein M et al. (1998) Does HIV/STD Prevention Counseling Work? Results From a Multicenter, Randomized Controlled Trail Evaluating Counseling Among STD Clinic Patients (Project RESPECT). Journal of American Medical Association 280: 1161-1167.
Subpopulation Researched Intervention Design Evaluated Outcome
General Project Respect. Five publicly funded STD clinics located in US inner cities (Baltimore, Denver, Long Beach, Newark and San Francisco). 5758 heterosexual HIV negative men and women who initially came to the clinics for STD diagnosis and treatment. Three face-to-face interventions: enhanced counseling (3-hours interactive sessions), brief counseling (2 40-minutes interactive session) and didactic message (personalized 10-minutes informational messages about HIV/STD prevention). 3 and 6-month follow-up visits, any condom use and consistent condom use were significantly higher among participants in both enhanced and brief counseling compared with control. Through the 6-month interval, 30% fewer participants had new STDs compared with control. Through 12 months, 20% fewer participants in each counseling intervention had new STDs compared with didactic group.
Comment: Supported by Branson et al. (1998) Sex Transm Dis 25: 553-559.
Higginbotham, S., Holmes, R., Stone, H., Beil, J., Datu, Costa, S., G.B., Paul, S., (2000) Adoption of Protective Behaviors Among Persons With Recent HIV Infection and Diagnosis--- Alabama, New Jersey, and Tennessee, 1997--1998. MMWR June 16, 2000/49(23); 512-515
Subpopulation Researched Intervention Design Evaluated Outcome
To examine risk behaviors (e.g., condom use and number of sex partners) after HIV diagnosis, CDC analyzed data on HIV Testing history and sexual behavior of persons who may have recently acquired HIV infection as part of a CDC sponsored study in Alabama, New Jersey, and Tennessee.  For purpose of the study, criteria for recent HIV infection included persons with diagnosed and reported HIV infection with CD4 T-lymphocyte counts >700 cells/ul or percentage>36, documented HIV seroconversion within 18 months of confirmed HIV infection diagnosis, or persons aged 13-24 years when diagnosed.  During January 1997 through September 1998, 615 persons with HIV infection diagnosed and reported met the criteria for the study.  These persons represented 15% of all persons reported with HIV in the three states.  Prior to diagnosis, the females reporting having vaginal sex with males and males reporting anal sex with males 25% reported never using a condom, 69% reported sometimes using a condom, and 6% reported always using condoms. Of the 543 persons eligible after follow-up, 180 persons completed the interview within 12 months of the self-reported date learning they were HIV infected (median: 6 months).  Among those, 99 (55%) were female; 96 (53%) were <25 years old; and 105 were non-Hispanic blacks, 49 were non-Hispanic white, 24 were Hispanic, and two self reported as “other”.  162 (90%) responded that they had changed their behavior since learning of their HIV infection.  After diagnosis, the females reporting having vaginal sex with males and males reporting anal sex with males, 30% reported not having sex, 6% reported never using a condom, 11% reported sometimes using a condom, and 47% reported always using condoms.  The number of sexual partners for the males and females decreased as well.
Further information can be found in The Revised Guidelines for HIV Counseling, Testing, and Referral (Adobe Acrobat, 110 pages) published by the CDC.  An alternative format of this publication is also available upon request.
Partner Notification - Heterosexual                                      Back to Top
Jordan WC, Tolbert L (1998) Partner Notification and Focused Intervention as a Means of Identifying HIV-positive Patients. Journal National Medical Association 90:542-6.
Subpopulation Researched Intervention Design Evaluated Outcome
General Los Angeles. 22 of 22 women, 5 of 8 heterosexual men and 6 of the 44 MSM interviewed were able to provide locating information on all of their enumerated/reported partners. Intervention divided MSM into two focus groups. Group 1 was asked: Who do you know that’s HIV positive and still practicing unsafe sex? Group 2 was asked: Who do you know that’s HIV positive but not in treatment? 13 of the 14 MSM in group 1 were able to identify 30 person they felt were still practicing unsafe sex; 17 of the 30 tested HIV positive and 9 were unaware of their status. Group 2 identified 15 people they felt were HIV positive. 11 were found to be HIV positive and 8 were unaware of their status.
Landis SE, Schoenback VJ et al. (1992) Results of a Randomized Trail of Partner Notification in Cases of HIV infected in North Carolina. New England Journal of Medicine 326:101-6.
Subpopulation Researched Intervention Design Evaluated Outcome
General North Carolina. Three local health departments. 162 participated, 54% declined and 46% agreed. 39 assigned to provider referral, 35 to patient referral. In provider referral, 70 of 157 partners successfully notified; patient referral, 10 of 153 notified. 23% of partners notified and tested were positive.
Pavia AT, Benyo M et al. (1993) Partner Notification for control of HIV: Results after 2 years of a Statewide Program in Utah. American Journal of Public Health 83:1418-24.
Subpopulation Researched Intervention Design Evaluated Outcome
General Utah. All persons reported in state over 2 years (308) 79% cooperated with 890 named partners with 70% located. Of those located 34% were previously positive. Of the remaining 2763 tested, 14% newly identified as infected. IDU, women and confidential (vs. anonymous) testers were more likely to cooperate and reported more partners. Cost: about $3,000 per new infection identified.
Rutherford GW, Woo JM et al. (1991) Partner Notification and the Control of Human Immunodeficiency Virus Infection. Two year of experience in San Francisco. Sexually Transmitted Disease 18:107-110.
Subpopulation Researched Intervention Design Evaluated Outcome
General San Francisco. 51 interviewed AIDS patients named 135 opposite-sex partners. 44%of partners located and interviewed, 25% tested, 5% HIV infected. Cost: $454 per partner notified. $2,203 per positive identified.
Toomey KE, Peterman TA et al. (1998) Human Immunodeficiency Virus Partner Notification Cost and Effectiveness Data From an Attempted Randomized Controlled Trial. Sexually Transmitted Disease 25:310-6.
Subpopulation Researched Intervention Design Evaluated Outcome
General New Jersey and Florida. 8 partners reported per case, one located per case. 25% previously positive. 75% of the remainder were tested. 22% positive. New positive partners per original case: 0.1. Cost: $250/index patient; $427 partner notified; $2,200 new infection identified.
Partner Counseling and Referral Services to Identified Persons with Undiagnosed HIV---North Carolina.  MMWR December 5, 2003/52 (48); 1181-118
Subpopulation Researched Intervention Design Evaluated Outcome
In 1989, North Carolina Department of Health and Human Services began offering PCRS to clients who tested positive in confidential and anonymous testing venues.  HIV infection became reportable in 1990 and anonymous testing was discontinued in 1997.  A trained disease intervention specialist (DIS) completed six important steps.  All notified partners received risk reduction counseling and appropriate referrals. Data collected from 2001 revealed a total of 1,603 persons were newly reported to have HIV infections.  DIS were assigned to conduct PCRS with 1,580 (99%) index clients, 1,378 (87%) were located and PCRS identified 1,532 sex or needle sharing partners.  1,359 partners were located and notified of their possible exposure to HIV.  After PCRS, from those who not previously testing positive for HIV, 108 newly tested partners were diagnosed HIV positive.

CDC Technical Guidance for Partner Notification and Referral Services

Procedural Guidance for Implementation of Partner Notification and Referral Services (Adobe Acrobat, 33 pages)  An alternative format of this publication is also available upon request.

Drug Treatment - Heterosexual                                               Back to Top
Shoptaw S, Frosch D, Rawson RA, Ling W (1997). Cocaine Abuse Counseling as HIV Prevention. AIDS Education and Prevention 9(6): 511-520.
Subpopulation Researched Intervention Design Evaluated Outcome
Non-IDU drug users Evaluated the efficacy of cocaine abuse counseling alone as a strategy to reduce HIV related sexual risk behaviors. Participants were 232 cocaine-abusing or dependent individuals who received up to 26 weeks of Matrix counseling but no formal HIV prevention interventions. 157 (67.6%) participants completed assessments at admission, during treatment, and at 6 months following admission. Participants located for follow-up were significantly more likely to be Caucasian, to be better educated, and to complete longer treatment episodes than those not located. Demographics: mostly heterosexual (89.9%), Caucasian (69.0%), crack cocaine users (65.6%). Main study findings indicated a significant association between safer sex behavior and completion of a cocaine abuse counseling episode. Participants who completed counseling were more likely to change to safer sex or maintain safer sex over the 6-month period than participants who terminated counseling prematurely. The primary method for reducing sexual risk involved overall decreases in reported numbers of partners (avg. at baseline = 5.32, avg. at 6-month follow up = 2.47)
Shoptaw S, Reback CJ, Frosch DL, Rawson RA (1998). Stimulant Abuse Treatment as HIV Prevention. Journal of Addictive Diseases 17(4): 19-32.
Subpopulation Researched Intervention Design Evaluated Outcome
Non-IDU drug users Individuals who use illicit stimulants, primarily cocaine and methamphetamine, engage in substantial amounts of HIV related sexual risk behaviors when under the influence. This paper presents the idea that reductions in stimulant use consequent to drug treatment makes stimulant drug treatment an important HIV prevention tool for this high–risk population. Presents data to describe HIV related sexual risks reported by out–of–treatment methamphetamine users and by cocaine and methamphetamine abusers at treatment entry and six months post treatment entry. Overall, findings demonstrate that following initiation of a treatment episode, stimulant abusers demonstrate significant reductions in HIV related sexual behaviors, primarily by reducing the number of sexual partners.
No reviews on Mass & Other Media, Social Marketing, Hotlines, and Clearinghouse for Heterosexual.                                                                                             Back to Top
 

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